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Take 1 capsule with or before meals, up to 3 times daily, or as recommended by your medical doctor. The American Association of Naturopathic Physicians (AANP) notes that berberine supplements are available as supplements or capsules.
Berberine A safer hypoglycemic agent for type 2 diabetes—Berberine
Berberine appears to activate AMP-activated protein kinase, which can help regulate how the body uses blood sugar. Researchers believe this activation can help treat diabetes and related health issues, such as obesity and high cholesterol. Berberine is an alkaloid compound that exerts antioxidant and anti-inflammatory activity, which translates to several health benefits, including: Concurrently, we should strengthen the mechanism of berberine in the treatment of vascular diseases. Novel technologies that could be employed to explore the mechanism of action of berberine in the treatment of vascular diseases include CRISPR–CAS-9 gene editing, metabolomics, proteomics, and genomics. Most importantly, recently published investigations of the pharmacological mechanisms of berberine may provide new insights into the treatment of vascular diseases by berberine. For example, Zhao and others demonstrated that 560mg/kg berberine administered orally in Coptis chinensis can significantly increase insulin secretion via the potassium voltage-gated channel subfamily H member 6 (KCNH-6) potassium channel in mice with HFD-induced hyperglycemia ( Zhao et al., 2021a). Overall, this study comprehensively reviewed and summarized the pharmacokinetics properties and therapeutic potentials of berberine in diverse vascular diseases, thus providing experimental evidence for future research to discover novel drugs from Chinese medicine monomers. Author ContributionsAt 1200mg per serving, Luma Nutrition Berberine offers the highest dose of berberine per serving (two capsules) on this list.
Berberine: A Review of its Pharmacokinetics Frontiers | Berberine: A Review of its Pharmacokinetics
Some research suggests that berberine works similarly to the drug metformin, which doctors often prescribe to treat type 2 diabetes. In fact, berberine may have the ability to change the bacteria in the gut, which could help treat both obesity and diabetes. Polycystic ovary syndrome In another study, the oral administration of berberine in 32 hypercholesterolemic patients for 3 months was shown to reduce serum levels of cholesterol by 29%, triglycerides by 35% and LDL-cholesterol by 25% ( Kong etal., 2004). Furthermore, the treatment of hyperlipidemic hamsters with berberine reduced serum levels of cholesterol by 40% and LDL-cholesterol by 42%, with a 3.5-fold increase in hepatic LDLR mRNA expression and a 2.6-fold increase in hepatic LDLR protein levels ( Kong etal., 2004; Yao etal., 2015). Berberine has also been shown to increase the abundance of Bacteroides, Parabacteroides, and Blautia genera, and eliminate or reduce the populations of Prevotella, Escherichia, Clostridium, and Sutterella genera in patients with hyperlipidemia ( Li etal., 2016).Given the beneficial effects on all these risk factors, it seems likely that berberine could reduce the risk of heart disease, though more research is needed. Summary Berberine is gaining popularity as a plant-based supplement to manage blood sugar and metabolic function—so much so that some people have dubbed it “nature’s Ozempic,” which is a diabetes drug that is now also being overly prescribed for weight loss.
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